Winters Bone By Daniel Woodrell

Winters Bone By Daniel Woodrell Winters Bone, written by Daniel Woodrell, tells the story of seventeen year old Ree Dolly and her struggles to save her family from the unfortunate circumstance that they have found themselves in. Deep in the Ozark Mountains of Missouri, where family ties are very important and all you have to do be beat up is ask the wrong questions, Ree is confronted with a clinically crazy mother, missing father and two young brothers too look after, as well as having only a matter of weeks before they are to be kicked off their own property. After her father Jessup Dolly, a well-known drug dealer and crank chef, fails to show for court, the law gives her only a few days to prove that there is a good reason that he didnt show before they claim the house that Jessup put up for his bond, where she, her mother and two younger brothers live. The reason, being that he is dead. There is no specific time period identified. However, it is safe to assume that is set in fairly recent times due to the techno logy mentioned such as Walkmans and television, as well as descriptions of modern types of cars. The novel has personal interest to me as Ree is the same age, yet in entirely different circumstances. The conditions that she has found herself placed under teach her to be very strong and have maturity beyond her years. These struggles are similar to those faced by the characters in the other texts that I have reviewed, such as Matty Ross in the film True Grit. Matty is also in a way in search of her father, except in her case it is more metaphorically than literally, as she goes on her quest to avenge her fathers death. She also is a young girl under unfortunate circumstances, who has to grow up very quickly in order to fend for herself. The novel is written in third person from an omniscient narrative point of view, focusing on Ree. This allows the reader to get a close perspective of Ree and her thoughts, letting them know what she does, yet still not being from her point of view. I personally enjoyed this perspective as at allowed me to feel closer to Ree and appreciate her outlook toward other characters as well as get a clearer idea her surroundings. This novel is similar in theme to The Hunger Games by Susanne Collins, in that the main character is a strong female of about the same age. Both Katniss and Ree are very protective of their younger siblings, Ree of Sonny and Harold, and Katniss of Prim, as well as having absent fathers and unsupportive mothers, leaving them to look after themselves as well as their siblings. They both are placed under unfortunate circumstances that force them to grow up prematurely and deal with things that people many years their senior would struggle to cope with. This plays on the sympathies of the reader, making them feel that the situation the character is in is unfair, making them want to read on to find vengeance. I believe that this text would be aimed at an older audience, as the writing style and themes involved would not be suitable for a younger audience. It is very poetic and well balanced, and would most likely be lost on the common fast paced style that is used in novels aimed at younger audiences to hold their attention. Themes like drugs and substance abuse, as well as physical abuse run throughout the text making it unsuitable for a less mature audience. It is my opinion that the book is beautifully written. It is a short book that avoids periphrasis and clichà ©, expressing only what is necessary to the imagery for the reader, making it dense and giving it the ability to hold the readers interest. It is almost poetic in the way that it is written, in that it uses a lot of imagery and gets a great deal of information out of a small amount of text, for example Fading light buttered the ridges until shadows licked them clean and they were lost to nightfall. There are also parts where what is going on is implied rather than explicit, allowing the reader to think about what is going on and read between the lines. I believe that the way that the author portrays Ree is appealing, a veiled heroine in a brutal environment, who refuses to yield to the ugliness of the society in which she lives. The general atmosphere of the text is quite sombre, however it does offer triumphant moments. The quality of writing is very different from that of The Hunger Games, which although has a good story line, is lacking in much writing technique and the language is rather colloquial. Winters Bone on the other hand is such a rich tale with a very broad dictation that helps to keep the audience captivated from beginning to completion. One of the scenes that I believe to be important to the readers perspective of Ree is the scene where she teaches her brothers how to hunt and skin squirrels. By doing this she is ensuring that they can look after themselves in future if she is not there to care for them. It is admirable how at the age of only sixteen she has practically raised them, and has the initiative to think of their futures and to protect them against any eventuality where she may not be able to look after them. She isnt stupid and knows the gravity of the situation she is putting herself in by going in search of her father, and still puts her familys well-being ahead of her own. Later on in the book after Sonny asks her if she will be leaving them for the army, Ree replies Naw. Id get lost without the weight of you two on my back. I believe that this quote accurately sums up her attitude toward her brothers, how she has been burdened with looking after them for so long that that she doesnt know what she woul d do otherwise. This novel turns out to be much more than a simple tale of a girl in search of her father. It unravels to be an admirable tale of a young heroine who refuses to let the brutalities of the world in which she lives get to her even when put under the most unpleasant circumstances. It carries strong messages of family ties and the worth of having the capability to refuse to take no for an answer. It is possibly the best written book that I have read of late, and I would not hesitate to endorse it if asked for recommendation. By Emily Moss

Essay --

Pharmacokinetic (PK) modelling plays a critical role in drug discovery and clinical pharmacotherapy of several types of drugs. PK modelling and simulation approach have been widely use to explain and predict PK profile of a drug. Several PK simulations are employed to measure estimated therapeutic window, dose selection, and to identify mechanism of action of chemicals and their metabolites in various tissues throughout the body. This integral component of drugs development process can be employed to investigate hepatic deposition of substrates. The data generated from such trial may be used to predict substrate deposition in vivo or to extrapolate deposition from animal to humans. For instance, measurement of transhepatic extraction in the isolated perfused rat liver permits assessment of hepatic clearance in vivo as the product of extraction and hepatic blood flow, assuming the flow is known. Hepatic clearance can them be predicted across mammalian species through incorporation of extraction into physiologically based PK models (Dedrick, 1974). There are different approaches to ph...

Identify Leadership Style Essay

As a leader, it sometimes takes a step back to look at oneself to realize what type of leader you are to understand your strengths and weaknesses, so you can lead an effective team to success. After lots of leadership quizs and readings, my leadership style is participative (Democratic) with an emphasis on the consensus view. â€Å"A participative leader seeks to involve other people in the process, possibly including subordinates, peers, superiors and other stakeholders. Often, however, as it is within the managers’ whim to give or deny control to his or her subordinates, most participative activity is within the immediate team (Tannenbaum and Schmitt, 1958).† Some of the characteristics of the participative leader and that of myself are: creating an atmosphere were creativity is wanted and rewarded, engaging in the group decision making process and while keeping the final say over decisions, allowing members to share ideas and thoughts. A1a: Two Strengths Using the participative leadership style gives me the most advantages when working and making decisions in a group. The main two strengths of my leadership style (participative) is: Empowerment and Better Team Decisions.  Empowerment: as defined by Dictionary.com, â€Å"v.–to give power or authority; to authorize, especially by official means. To enable or permit (Dictionary.com, 2014).† How does it feel when you feel like you have a say in a group or team? You feel valued. I enjoy allowing my team to feel valued and employ their decisions to make for the best decision possible. The feeling that group members get from participating makes the final decision accepted much more. Personally, when team members have input in the final goal, they feel responsible and take it much more seriously. Better Team Decisions: Since I don’t know all the answers, isn’t it better crucial to have lots of people helping find the answers. In my leadership style, since we have lots of people brain-storming on ideas, it makes for better team decisions. When a tough decision is ahead, its critical to have others helping make decisions. Employees input is invaluable in a group participating setting. When I allow others to help make decisions, the quality of those decisions will only increase. A1b: Two Weaknesses With this effective leadership style brings some cons. One of the cons of this style of leadership is time restrictions. When the team is liberated into making decisions, it takes awhile to come to great group decision. This type of leadership allows lots of discussions and hearing everyone’s opinions, which in-turn slows down the whole process. This style is a slower process, but the pro of making the best decision outweighs the con. The second con for this leadership style is that there can usually only be one decision and we as a team/group can not use everyone’s opinion or decision. This can cause some team members to become upset or heated, but can be avoided with a good leader leading the discussions. When allowing this style to be in a group, the group must come to a consensus in agreeing on the best decision and all parties must agree with whatever outcome is chosen. A2: Compare against two other styles Lets look at two other leadership styles and compare them to the participative leadership style. Authoritative (autocratic) which is a style that has clear expectations and usually makes decisions with little input from the team/group. In this style, the group makes fast decisions and the leader is usually the most knowledgeable team-member in the group Some similarities are that when the  team is in a bind or time is no longer of essence, the team leader must make an autocratic decision for the betterment of the group. The contributions of the team will be much lower than that of my participative style. Delegative (Laissez-Faire) is the opposite of the autocratic style in that there is little or no team guidance and the team is left to make all the decisions. This style is the least productive style because it offers no structure. The group is more likely to demand a lot from the leader and usually will not work independently. This style is used when all team members are over-qualified in the area of expertise, but also leads to lack of motivation for the group. The participating leadership style that I am apart of uses both the autocratic and the delegative style aspects to achieve maximum group potential. Participative leadership is concerned about the group and that the group has input. A3: Understanding to be more effective To be a leader you must have a mix of skills, behaviors, value sets and knowledge. To be a more effective leader one must understand their abilities and understand others and their strengths/weaknesses. This understanding includes an apprehension for other leadership styles. An impelling leader, understanding certain situations and leadership styles, can carry out different styles to lead different groups and teams of people. A great leader will supply assistance and encouragement to a group based on its needs and maintain the group by using its knowledge of different leadership styles. An effective leader can not accomplish success exclusive of a team. Those teams will consist of lots of team members and different leaders. An effective leader will be able to understand other leadership styles to support and assist those leaders. â€Å"The advantage to understanding your leadership style is that you understand your strengths and weaknesses. You can be proactive and more effective as a leader by strategically using your strengths and counteracting your weaker areas. Your style defines your values and perspective, and being aware of it will aid your communication those you work with. As the saying goes, knowledge is power. You can empower yourself and move forward in your career or interest by exercising this knowledge (Raines, 2011).† When knowing yourself and your leadership style it helps you in the workplace. Knowing your work environment and workplace challenges helps to address appropriate solutions using your leadership style. By knowing your style and the areas around you, it helps you make sound strategies for solutions to the problems and you can succeed by steering the strengths of the leadership way. Being a leader means that you must be able to know your strengths and weaknesses and the situations of the group and when to incorporate your style into the situation. Leadership is not a thing that fits all situations. The more leadership styles you are accustomed to, the more negotiable you will be able to be in the group. A4: Two problems in workplace due to different leadership Problem 1: An employee is always late for workplace. The schedule that the employee is on is one of rotating shifts (day and night). This involves different managers with different leadership styles. These different leadership styles has allowed this employee to continue its bad behaviors and continue to be late. Problem 2: Personality Clash. Your style is to talk out problems and solutions (democratic leadership style) while a manager you work with is direct and to the point (autocratic style), and doesn’t want to hear about the solutions but just wants the problems fixed. â€Å"Spray gun in tablet bed has stopped working, most of the team wants to find root cause, but one of the managers wants a solution now and doesn’t want to understand what caused  the problem.† A4a: Two ways to overcome each problem Problem 1: Late employee. The employee that is late knows that if LF (Laissez-Faire) manager is working that he allows an unstructured work environment. In other words, see nothing, hear nothing, speak nothing and all is correct in the work place. He has unclear expectations for this late employee and is more of people pleas-er that tackling the problem. This manager is fine if the employee is late as long as it does not effect production. This leadership style also allows him to play favorites. He has different rules for different people. As long as production is not affected, whats to bother? If AA (Autocratic) is manager, this employee knows that she can not be late to work, as is not for fear of consequences of her actions. They know that action will be taken against them if they are late. This causes a trickle down effect for employees, and their team morale. Since not all leadership team-members are on the same plane, things like this are always happening. We must fix this problem, before it gets out of hand. Fix. LF manager should first follow the rules and make the employee accountable for her actions. If that employee is late, they should have consequences like everyone else. If that does not work, then managers of this team should be aware of all times that employees are arriving and leaving work. During a monthly meeting, management could review all badge in/outs to make sure times are consistent with when employees are arriving and leaving. At these meetings, employees are questioned and held accountable for their tardiness. If this is not a viable option, management should have one manager that is responsible for all tardies/lates to work. This would be a dedicated job for the manager and take the responsibility off of the other managers and  help alleviate the leadership style differences between managers. Another quick fixer, would be to discuss this problem with LF manager and hold him accountable for allowing the employee to get away with tardies/lates. This one on one meeting would help to show him that there are consequences to his actions and that all employees need to be accountable for their actions. Problem 2: Spray gun. One way to fix this problem is to invite and have the said manager attend and hold discussions within the group to help him see that not all problems have immediate solutions. Allowing him on the team, helps him develop his leadership style and see there is not one leadership style that encompasses all problems. The leader must find it valuable for them to be on the team and to give input. Showing them that they are valued goes a long way to helping them develop as great leaders. Have a one on one with the manager to discuss reasons for and against having this meeting. If both parties that are having trouble understanding meet, then they are more apt to understand where each other is coming from. If this doesn’t work, we can always call an upper level management manager to help diffuse the situation. Another solution would be coaching. Maybe this manager/leader is insecure/uncertain about work environment or doesn’t want to make decisions because its not my job. Maybe this manager lacks creativity or innovation. Whatever the issue that they are dealing with, a great effective synergistic leader would see this as an opportunistic time to coach the manager in these areas to help alleviate stress, uncertainty and encourage teamwork, trust, expectations and cohesion amongst teams. A5a: Three advantages that increase productivity on these advantages â€Å"Taking a team from ordinary to extraordinary means understanding and  embracing the differences (Bennicasa, 2012).† The joint vision enables all groups to have meaningful communications—business synergy. Lets take a company that is going through a major brand transformation. The reasons not to change are abundant. The company was reaching goals and employee satisfaction was high. The company would lose brand identification through the proposed changes from upper management. The company would be dysfunctional because the whole team was not on board for the transformation. The change was a challenge from all parties involved. The bottom line came when management and the team members realized that those concerns did not compare to the importance of providing the best product and customer service to the customers. The shared vision had to be recognized from all that was serving through the transformation. The important factor was understanding that it was not about us anymore, but about the company’s greater good and we had to embrace it. Meetings were held, discussions were had about working together, being a better team, how to better serve our customers, and enabling team diversity. We had to see the team synergy to be able to grow and become a better productive team. New logos and mottos and so forth did not create team synergy, but leadership had to add value to the team and show all the team members that they were required to make a better team—that is business leadership synergy. Once team synergy was found, this allowed the team members to be accountable for their actions and this included the quality of the new products. In return, this created a better product for the customer. A second advantage of having a synergy leadership style could be used when different team members are not included in a process that affects them. When a team of engineers and managers are designing a new stream line approach to the production floor to help move along the packaging process of â€Å"M&Ms†. A synergy leadership approach to the stream line approach would be  to include the actual workers from the packaging floor. These employees would be able to discuss best practices for help in designing the new approach. This would speed up the meeting process and would speed up implementation of new processes because the packaging team members would be included in the process. Including these team members would allow for less trial and error and more time being productive in having the new packaging approach in a workable state. Having a synergistic team is just as important than the actual packaging process because it stream lines the meeting, allows team-members to have certain expectations, keeps the meetings focused on the problems and develops and enhances rich collaborative discussions that are now easy to have—business success. The third advantage of leadership synergy would be having all upper management in a participative meeting discussing the new vision for the company. After long discussions the team has selected the vision for the company. The team then selects an authoritative figure to disburse the new vision information to the whole company group—because its not up for debate anymore. Knowing when to use different leadership roles is very important. In this model, a decision that has the absolute consensus of all upper management, will appear when all team-members is seeing the discussion directly through the same glasses – which includes the mission, the vision and the teams goals. Without these glasses, cooperative judgments can be challenging to accomplish. The hard part of making decisions and agreeing upon them in a multi-leadership style team –is that there is no common goal – changes in leadership styles will strangle the discussions, as more thoughts will only add to the difficulty in making a decision. Looking through the same lenses of the glasses permits a variety diversity into the debate and allows the group to succeed. Once we see everything through the same lens, then the upper management group  can be more productive in delivering a vision in a timely manner. This synergy of upper management leaders then starts trickling down to management teams throughout the plant and then onto regular teams and committees in the plant. This trickle down affect makes teams more productive, more efficient by allowing the meetings to flow better and to free up people to not be in meetings (to be on the floor being productive making the products). References Bennicasa, Robyn. (2012) 6 Leadership Styles, and When You Should Use Them. Retrieved from http://www.fastcompany.com/1838481/6-leadership-styles-and when-youshould-use-them. Dictionary.com. 2014. Empowerment Definition. Retrieved from http://dictionary. reference.com/browse_empowerment Raines, Stephanie. 2011. The Advantages of Knowing Your Leadership Style. Retrieved from http://smallbusiness.chron.com/advantages-knowing leadership-style18924.html. Tannenbaum, A.S. and Schmitt, W.H. (1958). How to choose a leadership pattern. Harvard Business Review, 36, March-April, 95-101.

Chromatography of Commercial Analgesics - 878 Words

Chromatography of Commercial Analgesics Using the thin layer chromatography the major components of a commercial analgesic tablet will be indentified and purified. The active ingredients of the analgesic used were characterized by comparison with chromatograms of aspirin, acetaminophen, ibuprofen, mefanemic acid, and caffeine through the use of UV chromatography then the Rf value was calculated for each solvent. INTRODUCTION In this experiment, thin-layer chromatography (TLC) will be used to determine the composition of various analgesics. Chromatography is a technique used to separate and identify individual components in a mixture. Chromatographic techniques make use of the fact that components of a mixture tend to move at†¦show more content†¦This experiment aims to indentify and characterize the major components of commercial analgesic tablets which in this case the assigned tablet was Ibuprofen Alaxan. MATERIALS AND METHODOLOGY I. Preparing the TLC plates Cut a 5x10 TLC plastic sheet. six mark spots must be placed so that the solvents will be placed properly later on through the capillary, this marks must be 1cm apart and 1cm from the bottom edge of the TLC sheet. II. Preparing the Sample The sample analgesic was triturated with 2ml methanoltoluene it was then decanted and transferred into a vial. The standards that were used were already prepared, the aspirin, acetaminophen, ibuprofen, mefanemic acid, and caffeine. III. Sample Application Using a capillary tube, one end was dipped in the sample solution to allow the solution to enter by capillary action. On one end, using the index finger block the top-end of the capillary, lightly and then quickly spot it to the mark on the TLC plastic sheet. Using new capillary tubes, repeat the same process for the other spots for all. IV. 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